U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 1 - 10 of 39 results

Perindopril arginine is a stable L-arginine salt of perindopril. Perindopril, a pro-drug, is hydrolyzed to perindoprilat, which inhibits ACE in humans and in animals. It is indicated for the treatment of hypertension, heart failure and coronary artery disease. Perindopril arginine may be used in monotherapy or in combination with other classes of antihypertensive therapy.
Status:
Other

Class (Stereo):
CHEMICAL (RACEMIC)



(±)-3A,7A-di-epi-Perindopril is a mixture of two isomers (S, RR, SS) and (R, SS, RR) each of which is an isomer of the antihypertensive drug perindopril. The first of which has the same activity as the compound while the second one is almost inactive.
Status:
Other

Class (Stereo):
CHEMICAL (RACEMIC)


(1''R,3AR)-1'',3A-di-epi-Perindopril is an epimer (S, RS, SR) of the drug perindopril which is commonly used to treat high blood pressure, hypertension, heart failure, or stable coronary artery disease. This form of the drug is much less active than the parent compound, perindopril.
Status:
Other

Class (Stereo):
CHEMICAL (RACEMIC)


(2R,2'R)-2,2'-di-epi-Perindopril is an epimer (R, SS, RS,) of the drug perindopril which is commonly used to treat high blood pressure, hypertension, heart failure, or stable coronary artery disease. This form of the drug is much less active.
Status:
Other

Class (Stereo):
CHEMICAL (RACEMIC)


(2R,7AR)-2,7A-di-epi-Perindopril is an epimer (R, SR, SS) of the drug perindopril which is commonly used to treat high blood pressure, hypertension, heart failure, or stable coronary artery disease. This form of the drug is much less active.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)


(±)-1'',2-di-epi-Perindopril is a mixture of two isomers: (S, SS, RR) and (R, RR, SS) which are both epimers of the antihypertensive drug perindopril and almost inactive.
Status:
Other

Class (Stereo):
CHEMICAL (RACEMIC)


Conditions:

(±)-2,3A-di-epi-Perindopril is a mixture of two isomers (S, SR, RR) and (R, RS, SS) which are both inactive epimers of the antihypertensive drug perindopril, although the (R, RS, SS) isomer possesses better activity.
Status:
Other

Class (Stereo):
CHEMICAL (RACEMIC)


(±)-2',7A-DI-EPI-PERINDOPRIL is a mixture of two isomers (S, SR, RS) and (R, RS, SR) which are both almost inactive epimers in of the antihypertensive drug perindopril.
Status:
Other

Class (Stereo):
CHEMICAL (RACEMIC)


(2'R,3AR)-2',3A-di-epi-Perindopril is an epimer (S, RS, RS) of the drug perindopril which is commonly used to treat high blood pressure, hypertension, heart failure, or stable coronary artery disease. This form of the drug is much less active.